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Download PDF by D. W. van Bekkum (auth.), Professor Georges Mathé (eds.): Advances in the Treatment of Acute (Blastic) Leukemias

By D. W. van Bekkum (auth.), Professor Georges Mathé (eds.)

ISBN-10: 3662349981

ISBN-13: 9783662349984

ISBN-10: 3662353342

ISBN-13: 9783662353349

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A girl aged 6 with acute lymphoblastic leukaemia who had previously received prednisone, vincristine, methotrexate and cyclophosphamide was given 1-asparaginase and within 72 hours the blast cell count in the peripheral blood feil from 250,000/cu mm to zero. However, the bonemarrow still contained blast cells after 21 days of treatment, but at the end of the course (i. e. 28 days) these had disappeared and a complete remission was obtained. During this period intra-thecal methotrexate had to be given for cerebralleukaemia, but the blood had been cleared of leukaemic cells before methotrexate was used.

Discussion at the Internationale Arbeitstagung über Chemo- und Immuntherapie der Leukosen und malignen Lymphome. Wien/Austria, March 1969. 4. DoLOWY, W. : Toxic and antinoplastic effects of L-asparaginase. Cancer 19, 1813 (1966). 5. GALLMEIER, W. , ScHMIDT, C. , STIER, H. : In-vitro-Testung von Zellen auf Asparaginmangelempfindlimkeit in Chemo- und Immunotherapie der Leukosen und malignen Lymphome. Hrsg. A. STACHER. Wien: Bohmann Verlag 1969, p. 30. 6. HASKELL, c. , CANELLOS, G. , LEVENTHAL, B.

Effect of L-asparaginase on various factors of the hepatic function and hemostasis The other hepatic factors are little or not disturbed. 48 g/1 after 15 days of L-asparaginase 50,000 U/day. 4. Effects on the Immunological Functions These are difficult to evaluate directly in Man, even in cases of treatment of subjects in non-visible phase of their leukaemia; in fact, the treatment by L-asparaginase succeeds immunosuppressive antimitotic treatments and the comparison of results obtained before and after treatment by L-asparaginase have therefore little significance.

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Advances in the Treatment of Acute (Blastic) Leukemias by D. W. van Bekkum (auth.), Professor Georges Mathé (eds.)


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